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San Francisco enters its Sunday, Oct. 4, 2026 matchup with Denver at Levi’s Stadium at 3-0, while the Broncos are 2-1. The 49ers’ path to a fourth straight win is to keep Brock Purdy protected, sustain their early-down and scoring efficiency, make Christian McCaffrey and George Kittle hard to contain, and prevent Denver from finding a productive run game or creating short fields.
This is a pregame look at the matchup; the game has not yet been played. The statistics below are season-to-date through three games, as reported in the cited team previews and updates.
1. Keep Brock Purdy clean and on schedule
San Francisco’s protection has been a major strength: the 49ers had allowed zero sacks through three games, according to the team’s season report. Purdy had thrown for 789 yards and nine touchdowns in that span. Denver presents a meaningful test of that record: the Broncos had eight sacks, including three by defensive lineman Zach Allen, through their first three games, per Denver’s Oct. 2 preview.
The aim is not simply to preserve a streak. Protection that gives Purdy time to work through reads can keep the offense on schedule and make Denver defend the full playbook. If pressure disrupts timing, San Francisco risks losing the efficiency that has helped its passing game thrive.
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2. Win third down and finish red-zone drives
Denver’s Oct. 2 preview said the 49ers ranked first in both third-down conversion percentage and red-zone touchdown percentage through three weeks. San Francisco had scored touchdowns on nine of its ten red-zone trips in that three-game sample. Those figures point to two linked priorities: avoid putting Purdy in long third downs, then turn scoring chances into touchdowns rather than settling for less.
The numbers describe a short early-season sample, not a guarantee. Denver’s defense can make the 49ers’ task harder by creating negative plays on early downs or forcing third-and-long situations.
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3. Make McCaffrey and Kittle difficult to account for
McCaffrey gives San Francisco a threat as both a runner and receiver. The 49ers listed him with 166 rushing yards and 13 receptions through three games. Denver’s preview separately reported 270 scrimmage yards and three touchdowns for McCaffrey; those are that source’s figures and should not be combined with the 49ers’ listed rushing and reception totals as though they were one stat line.
Kittle adds another difficult matchup. The 49ers reported 174 receiving yards and three receiving touchdowns for the tight end through three games. When McCaffrey and Kittle can contribute in different parts of the offense, Denver must account for more than one focal point. Their varied usage can help keep the defense from concentrating solely on San Francisco’s wideouts.
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4. Make Denver earn the run early
Denver averaged 81.0 rushing yards per game through three weeks, according to the Broncos’ matchup preview. Its first-half rushing totals were 23 yards against Kansas City, 32 against Jacksonville and 21 against the Rams. Head coach Sean Payton acknowledged the slow starts: “I would say this: we haven’t run the ball in the first half of any of those three games,” and, “We haven’t run it consistently well enough, clearly.”
San Francisco should try to keep those early-down problems going and make Denver sustain longer drives. But the 49ers cannot treat this as a guaranteed mismatch: they were allowing 105.7 rushing yards per game through three weeks, according to Denver’s preview. The defensive priority is to limit efficient runs before Denver can use them to create manageable passing situations.
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5. Avoid turnovers and protect field position
Denver’s eight sacks through three games give it a route to disrupting San Francisco’s offense; pressure can lead to hurried throws, lost yardage or turnover chances. The 49ers, meanwhile, reported that safety Talanoa Hufanga intercepted two passes against the Rams the previous week. That recent production offers a reminder of how much a takeaway can change a game, but it is not a promise of another two-interception performance.
The practical approach follows from the matchup: protect the ball, avoid negative plays that invite pressure, and make Denver drive the length of the field. This is a strategic inference from the teams’ reported pressure and turnover production, not a publicly stated list of coaching keys.
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49ers availability entering the game
San Francisco’s Oct. 2 injury update listed Nick Bosa (knee/calf), James Thompson Jr. (ankle) and Mykel Williams (knee) as out. Mike Evans (ribs), Dre Greenlaw (quadricep), Keion White (hamstring) and Jaden Dugger (shoulder) were questionable; Evans and Greenlaw returned to limited practice Friday. Trent Williams had no game designation after participating fully Friday. These are the team’s reported Oct. 2 statuses, not a substitute for the game-day inactive list.
Game details
The Broncos’ official game guide listed kickoff for Sunday, Oct. 4, at 2:25 p.m. MT at Levi’s Stadium. Broadcast and streaming availability depends on location and subscription. The guide identifies Paramount+ for local streaming, NFL+ for local games on mobile, and NFL Sunday Ticket for out-of-market Sunday afternoon games. Check the Broncos’ official game guide and local listings for current availability.
Quick Recap
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