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To damage Bio-Bulkhead, throw a Locust Sample at it whenever it becomes immune. The boss is in Synthetic Nave in the Dissected Plateau, Fadefields, during the main mission One Fell Swoop. Its listed legendary chance drops are the Budget Deity pistol, Sho Kunai grenade, and Waterfall grenade.
Where to find Bio-Bulkhead
Bio-Bulkhead appears in Synthetic Nave, within the Dissected Plateau region of Fadefields, as part of One Fell Swoop. The location and encounter are listed by Game8 and Mobalytics.
How to get past Bio-Bulkhead’s immunity
- Pick up a Locust Sample from the arena when Bio-Bulkhead becomes immune. Game8 says immunity occurs at the start of the fight and at the beginning of each health segment.
- Throw the sample at Bio-Bulkhead to end the immunity phase and make it vulnerable to damage.
- Attack while it is vulnerable. Game8 recommends corrosive or cryo weapons and jumping over the boss’s area attacks. The guide does not establish a damage multiplier or precise timing window.
Bio-Bulkhead’s legendary drops
Game8 and Neoseeker list three legendaries associated with Bio-Bulkhead. These are chance drops, not guaranteed rewards; the guides do not establish a reliable drop percentage or expected number of attempts.
| Item | Type | Listed effect |
|---|---|---|
| Budget Deity | Legendary Tediore pistol | Its D.O.P.E. Buoys effect throws two Combo Orbs that apply Atlas Target Lock to enemies hit, according to Game8. |
| Sho Kunai | Legendary grenade ordnance | Neoseeker describes its Ninja Speed trait as granting +10% movement speed per hit, stacking up to seven times. |
| Waterfall | Legendary grenade ordnance | Neoseeker says it creates additional explosions when it damages targets. |
The two grenades offer different listed effects, while the Budget Deity occupies the pistol slot. The descriptions above identify item behavior; they do not establish an overall strength ranking.
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How to repeat the fight
After completing One Fell Swoop, return to the arena and use the Moxxi’s Big Encore Machine near its entrance to fight Bio-Bulkhead again. Game8 and Neoseeker document repeat access, but do not establish the machine’s current cost. Availability or encounter details may change with game updates; the cited guides are secondary sources rather than an official publisher reference.
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