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How to Complete The Slithering Dead in Path of Exile 2

The Slithering Dead walkthrough: reach the Den of the Serpent Priestess in The Venom Crypts, collect Corpse-Snake Venom, and bring it back to Servi.
WorldPath of Exile 2 Length2 min Posted Quest giverVGSources Team
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To complete The Slithering Dead in Path of Exile 2, find the Corpse-Snake Venom in the Den of the Serpent Priestess inside The Venom Crypts, then return it to Servi at the Ziggurat Encampment. The corpse’s exact position varies, so use the nearby checkpoint and three-pointed cavern as landmarks rather than relying on fixed coordinates.

Start the quest and reach The Venom Crypts

The Slithering Dead takes place in Act 3 and connects Jungle Ruins, The Venom Crypts, and the Ziggurat Encampment. Entering The Venom Crypts is associated with unlocking the quest; if it has not appeared in your objectives, return to the Ziggurat Encampment and speak with Servi before continuing.

From Jungle Ruins, find the entrance to The Venom Crypts near the area waypoint and go inside. Game8’s quest guide identifies entering the crypts as the unlock condition, while Gamer Guides’ walkthrough directs players to speak with Servi to start the quest.

Find the corpse in the Den of the Serpent Priestess

Explore The Venom Crypts until you locate the Den of the Serpent Priestess. The corpse is in a three-pointed cavern reached through a narrow passage, with a checkpoint outside. Its placement is randomized, so the cavern and checkpoint are more useful than expecting it at a particular map coordinate.

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Search the corpse and collect the green-text quest item, Corpse-Snake Venom. The Path of Exile 2 Wiki’s quest entry also identifies the item as the objective.

Return to Servi and complete the objective

  1. Leave The Venom Crypts and return to the Ziggurat Encampment.
  2. Speak with Servi and give her the Corpse-Snake Venom.
  3. Follow the remaining quest prompt to take and consume the Venom Draught if that step appears in your version.

PoE2 Ref reproduces Servi’s dialogue after the handoff: “Heh heh. Drink this. A foul brew, but you’ll thank me… if you survive.” It is in-game NPC dialogue, not a guarantee about the effect of every version’s reward.

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Choose a reward based on your version and build

Reward details differ between references and may depend on the game version. Gamer Guides and PoE2 Ref list three Venom Draught choices, while the Path of Exile 2 Wiki search excerpt reports an Artificer’s Orb and notes that a mana-regeneration benefit changed when Cruel Difficulty was removed in version 0.3.0. The wiki page was not accessible, so the available information does not establish which reward set is currently live for every player. Check Servi’s reward interface before choosing.

Reported draught Reported effect Best fit if offered
Venom Draught of Stone 25% increased Stun Threshold Characters that benefit from greater stun resilience
Venom Draught of the Veil 30% increased Elemental Ailment Threshold Characters that need more resistance to elemental ailments
Venom Draught of Clarity 25% increased Mana Regeneration rate Characters that need stronger mana sustain

The draught effects above are the values reported by Gamer Guides; its walkthrough was last updated in January 2025. The references do not establish a universally best choice. If the three options are presented, choose according to your character’s needs rather than assuming one is optimal for every build.

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