In The Binding of Isaac: Rebirth, the standard Chapter 2 boss roster has 17 bosses according to the Binding of Isaac Rebirth community wiki. Chapter 2.5 is a separate set of eight bosses and should not be counted in that total.
Which game this list covers
“Chapter 2 boss list” does not point to one game. Searches for the phrase also return Chapter 2 boss lists for Black Myth: Wukong and Deltarune, and this article does not cover either of them. The closest exact-title match is The Binding of Isaac: Rebirth, so the roster below applies to that game.
Standard Chapter 2 roster in Rebirth
The community wiki lists these 17 Chapter 2 bosses, in the order its page presents them:
- Fistula
- Chub
- C.H.A.D.
- Gurdy
- Mega Fatty
- Mega Maw
- Gurdy Jr.
- Peep
- The Husk
- The Hollow
- Carrion Queen
- Dark One
- Polycephalus
- The Wretched
- Pestilence
- The Fallen
- Headless Horseman
The wiki classifies The Fallen and Headless Horseman as universal bosses. They are not limited to Chapter 2, so they can appear in other chapters as well.
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Chapter 2.5 is a separate list
The same wiki page includes a Chapter 2.5 roster. Keep these eight bosses apart from the standard Chapter 2 list:
- Reap Creep
- Tuff Twins
- Hornfel
- Great Gideon
- The Pile
- The Shell
- Singe
- Clutch
Bosses absent from base Rebirth
The wiki marks three names as not present in Rebirth: The Stain, The Frail, and The Forsaken. If you are following a guide or video that names them in Chapter 2, it is probably describing a different version of the game.
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Afterbirth and Repentance additions
The same page lists Big Horn and Rag Mega as appearing in Afterbirth, and Bumbino as appearing in Repentance. The wiki entries do not show where each one sits within those expansions’ chapter structure, so treat them as expansion content rather than part of the base Rebirth roster of 17.
Independent reader supportYour contribution helps us test, update, and keep practical guides available for everyone.How reliable this list is
The roster comes from a community-edited wiki, not from the developer’s own documentation. Wiki pages can lag behind game updates, so check the list against the version you are playing before relying on it for a run, a challenge, or a guide.
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