Full ending spoilers ahead. High on Life 2 guides describe three hidden payoff routes: shoot Lizzie during the opening encounter for an abrupt credits sequence, finish the campaign and wait through the credits for playable post-credits content, and complete Twilly’s optional escape rooms before the finale to unlock a staged hidden reveal. Guides count these outcomes differently, so this is a practical route guide—not an official, confirmed total.
At a glance: which route should you take?
| Route | When | What you need | Payoff |
|---|---|---|---|
| Shoot Lizzie | First mission | Reach Lizzie’s first encounter | Credits, a funeral image, and the Good Ending achievement, according to Destructoid |
| Campaign post-credits section | After the main story | Defeat Nipulon and let the credits finish | A playable scene with characters reacting to your victory and a message from Suit OS, as described by Destructoid |
| Twilly’s escape-room reveal | Escape rooms before the finale; reveal after the final boss | Reach Pinkstock Harbor, use Travis to access Twilly’s No Escape, and finish all three rooms | A staged room sequence and hidden reveal, as described by Gameranx |
1. Get the early Lizzie credits route
In the first mission, the intended path is to help Lizzie by taking out the bounty hunters. To trigger the abrupt alternate route instead, shoot Lizzie when you first meet her. Destructoid reports that the game rolls the credits, shows an image of Lizzie’s funeral, and awards the Good Ending achievement.
| # | Preview | Product | Price | |
|---|---|---|---|---|
| 1 |
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High on Life 2 - PlayStation 5 | $39.99 | Buy on Amazon |
| 2 |
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High on Life 2 (Playstation 5) | $41.99 | Buy on Amazon |
| 3 |
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High on Life - PlayStation 5 | $59.99 | Buy on Amazon |
| 4 |
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The Diofield Chronicle - PlayStation 5 | $22.77 | Buy on Amazon |
| 5 |
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007 First Light - Specialist Edition - PlayStation 5 | $69.99 | Buy on Amazon |
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This is a joke ending that cuts off the campaign early; it is not the main story’s conclusion. If you want to continue the standard campaign, do not shoot Lizzie at this encounter.
2. See the campaign’s post-credits playable section
Follow the main missions through the confrontation with Nipulon. After defeating him and stopping his plan, stay through the credits rather than exiting or skipping ahead. Destructoid says a playable section begins afterward, featuring characters praising you for stopping Nipulon and a message from Suit OS.
#1 Best Overall
- An intergalactic conspiracy threatens the fate of humanity! Team up with a wide cast of talking alien guns as you shoot, stab, and skate your way through the exotic locales to take down the bad guys and save your favorite species (humans)!
- Kickflip alien cops in the face and grind your way to freedom with your brand new SKATEBOARD.
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This is post-credits content attached to the standard campaign route, rather than a separate choice-based ending.
3. Unlock the Twilly escape-room reveal
Complete the optional escape-room quest before finishing the main story. Games.GG warns that the achievement tied to this content is missable if you leave the rooms until after the campaign ends. The access route and final trigger below follow Gameranx; the puzzle solutions and newsletter detail follow Games.GG’s guide.
Rank #2
- BLAST your way through enemies with an arsenal of charismatic alien firepower in high-octane hyperactive combat.
- Kickflip alien cops in the face and grind your way to freedom with your sick-as-hell new SKATEBOARD.
- Cut it up with an eccentric cast of bizarre and subversive lifeforms who all think you’re HOT AS HELL.
- Wreak havoc at the galaxy’s biggest convention, get lost in the mysterious woods of a medieval planet, and slash your way through the belly of a sea beast on your cosmic quest to take down Big Pharma.
Reach Twilly’s No Escape in Pinkstock Harbor
- Complete the Pinkstock assassination mission on the Pinkline, reach Pinkstock Harbor, and obtain Travis.
- Find the small mall area by the train station. Use Travis’s ability to raise the broken lift, then ride it to the upper floor.
- Enter Twilly’s No Escape attraction and agree to test its escape rooms. Once you start, the side quest locks you into its sequence.
Complete all three rooms and collect the ankhs
- Mummy room: Interact with the alarm clock to wake the mummy.
- Doghouse room: Cook the raw meat on the barbecue, then put it by the doghouse.
- Chainsaw room: Fuel the chainsaw and use it on the mummy. Take the ankh, then place the body on the bed.
These puzzle solutions come from Games.GG. After leaving the attraction, that guide advises accepting the newsletter prompt; treat this as a guide-reported step, not an officially confirmed condition.
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- Finish the main campaign and defeat the final boss.
- At the restaurant gathering, leave through the exit blocked by the characters, as Gameranx describes.
- Interact with the glowing ankh on the floor outside the circle. The restaurant transforms into a staged room; follow the sequence there to see the hidden reveal.
The guides differ in how they describe when to initiate the finale sequence. The cautious order is to finish the rooms before completing the story, then look for the glowing ankh at the restaurant after the final boss.
Rank #3
- Includes Base Game + High on Knife DLC content on disc
- Become the deadliest intergalactic bounty hunter the cosmos has ever seen with your team of charismatic talking guns
- Navigate dynamic and changing worlds in this hilarious and unique first person shooter
- Leverage the distinct skills of each gun to defeat a variety of enemies
- Travel to a variety of biomes and locations across the cosmos, go up against the nefarious Garmantuous and his gang of goons, collect loot and meet unique characters
Why guides give different counts
Destructoid’s February 2026 guide calls two outcomes secret endings: the Lizzie credits route and the campaign’s post-credits section. Gameranx separately documents the escape-room reveal. Because those guides use “ending” differently and no official inventory of all endings is established by these sources, the useful distinction is what each route actually does: an early credits gag, playable content after the credits, or a hidden sequence reached through optional rooms.
Quick Recap
Best Value
- ONLY AT AMAZON - SPECIALIST EDITION
- EARN THE NUMBER - Discover a new James Bond origin story, and the events that led a young maverick to become the best MI6 agent.
- A THRILLING ESPIONAGE ADVENTURE - Embark on missions in breathtaking locations, drive iconic vehicles, and dive into a cinematic adventure in pursuit of a rogue agent who’s always one step ahead.
- SPYING, YOUR WAY - Go silent or go loud. Whether fighting with fists or firepower, using gadgets to infiltrate, or bluffing your way past guards, the approach is entirely up to you.
Rank #4
- New Strategy RPG by Square Enix - An all-new Strategy RPG that chronicles an epic tale of war and honor; Featuring a unique and beautiful world that blends fantasy, medieval and modern-day influences, and a deep yet innovative real-time battle system
- Deep, strategic, real-time tactical battles – Make real-time assessment of battlefield conditions and decisive orders that take advantage of your troops strengths and weaknesses; Make use of skills, classes and equipment to complete your mission
- Realistic diorama style battle scenes - Richly detailed depictions of the environments of the island of DioField combined with unique "diorama" style visuals as you command your forces like a general
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